A Research of pleasant sounds those bring human relaxation, based on the neural mechanism of instinct.

我探索了对人类有吸引力的声音，并在人类和老鼠身上研究了这些有吸引力的听觉刺激的物理效应。人类考生被暴露在由几种声音（如手表、小波、音乐）和白噪声组成的听觉刺激序列中。在一项面试研究中，其中一些声音被考生认为是有吸引力的。近红外光谱研究表明，在有吸引力的声音刺激下，额叶皮层的活动是稳定的。我把老鼠放在一个控制声光条件的盒子里。小鼠接受12小时（20:00-8:00）有吸引力的声音刺激，持续一周。声音暴露期结束后，处死小鼠，用高效液相色谱法测定小鼠脑内单胺浓度。接触声音的小鼠大脑额叶区血清素浓度高于沉默小鼠。这些结果表明，5 -羟色胺能系统可以参与声音的吸引力的物理效应。

I explored the attractive sounds for human, and physical effects of those attractive auditory stimulations were examined in both of the human and the mouse. Human examinees were exposed a sequence of auditory stimulation which are composed of several kinds of sound (ex. watch, wavelets, music) and white noise. Some of these sounds were judged as attractive by the examinees in an interview study. A near infrared spectroscopic study revealed that the activity of the frontal cortex were stable during the attractive sound stimulation. I kept mice in a box that controlled sound and light condition. The mice were exposed twelve hours (20:00-8:00) of the attractive sound stimulation for a week. After the sound exposing period, the mice were sacrificed and monoamine concentration in their brain was measured by high performance liquid chromatography. Concentration of serotonin in the frontal brain region of the sound exposed mice was higher than the mice kept in silent. These results suggest that serotonergic system can be involved in the attractive physical effects of sounds.