Micro-simulation for inhaled particle tracking using image-based model human airways

采用计算流体动力学(CFD)方法对基于X射线CT图像构建的人体呼吸道三维真实感模型中的颗粒在振荡流动中的跟踪进行了研究。颗粒跟踪表明，在分叉口具有流动分离的方向相关的速度分布促进了轴向流体在气道中的扩散。在小气道扩张和收缩模型中，颗粒的方差随体积变化的增大而增大。

Computational fluid dynamics (CFD) simulations were carried out for particle tracking in oscillatory flow in a 3D realistic model of the human airways constructed based on X-ray CT images. Particle tracking revealed that the direction-dependent velocity profile with flow separation at the bifurcation promotes axial fluid dispersion in the airways. It was also found that the variance of the particles increases with the increase of volume change in an expanding and contracting model of small airways.