Application of hydrogels for adhesion prevention after thoracotomy

交联型聚γ-谷氨酸(PGAXL)是一种可生物降解的聚合物，能够形成水凝胶。在本研究中，我们使用小鼠开胸手术模型，研究局部应用PGAXL是否可以减少开胸手术部位的粘连形成。我们发现，局部应用PGAXL可减少开胸部位肺与壁胸膜以及胸壁与胸肌之间的粘连形成。

Cross-linked poly (gamma-glutamic acid) (PGAXL) is a biodegradable polymer capable of forming a hydrogel. In the present study, using a mouse model of thoracotomy, we investigated whether local application of PGAXL could attenuate adhesion formation at the thoracotomy site. We found that local application of PGAXL attenuated adhesion formation at the site of thoracotomy between the lung and the parietal pleura as well as between the chest wall and the chest muscles..