Osteoimmunological study in the occurrence of orthodontically root resorption

RANKL和IL-17在重度牙根吸收组的升高幅度大于无牙根吸收组。此外，IL-17以时间和剂量依赖性方式刺激人PDL细胞产生RANKL。从第7天开始，在牙根吸收区的成骨细胞、破骨细胞、破牙细胞和牙周韧带成纤维细胞中，抗破骨细胞生成的免疫反应（RANK、RANKL、c-fms、M-CSF、IL-1 β、IL-6、IL-17、IL-17 R、CD 4）变得更强。IL-17/RANKL系统负责将重机械负荷信号转导成牙根吸收中的破牙事件。

The increase of RANKL and IL-17 were greater in the severe root resorption group than in the non-resorption group. Further, IL-17 stimulated RANKL production from human PDL cells in time- and dose dependent manner. Immunoreaction against osteoclastogenesis (RANK, RANKL, c-fms, M-CSF, IL-1 beta, IL-6, IL-17, IL-17R, CD4) became stronger in osteoblasts, osteoclasts, odontoclasts, and fibroblasts of the periodontal ligament in root resorption area from Day 7 onwards. The IL-17/RANKL system is responsible for transducing the heavy mechanical loading signals into an odontoclastic episode in root resorption.