Covalent Immobilisation of Growth Factors on Plasma Modified Titanium for Achieving Enhanced Bone Growth and Bonding in Implant Prosthetics

该项目旨在通过将南澳大学和弗林德斯大学的表面技术专业知识与TGR BioSciences的生长因子专业知识相结合，改善钛植入物的固定。等离子体改性和羟基磷灰石涂层的植入物表面将用于通过具有定制的润湿性和柔性的系链共价固定生长因子。这一创新策略预计将产生高保留生长因子的生物活性和增加骨植入物的长期稳定性的整合。开发的知识，专业知识和技术将有助于TGR BioSciences扩大其研究基础和业务。另一项主要成果是在新兴的纳米生物技术领域培训学生。

This project is aimed at improving the fixation of titanium implants by combining the surface technologies expertise of University of South Australia and Flinders University with TGR BioSciences's growth factors expertise. Plasma modified and hydroxyapatite-coated implant surfaces will be used for covalent immobilisation of growth factors via tethers with tailored wettability and flexibility. This innovative strategy is expected to yield high retention of growth factor bioactivity and increased bone-implant integration for long-term implant stability. Knowledge, expertise and techniques developed will help TGR BioSciences expanding its research base and business. Training of students in the emerging field of nano-biotechnology will be another major outcome.