Roles of ER stress in renal pathophysiology and development of novel therapeutic approaches to kidney diseases

未折叠蛋白反应(UPR)有两个不同的方面：抗炎方面(光明面)和组织破坏潜力(暗面)。内质网(ER)应激后，UPR的不同分支参与了暗面和亮面的形成。通过调节UPR的选择性臂，可以减轻炎症反应，抑制内质网应激引起的组织损伤。3‘-脱氧腺苷和4-苯基丁酸类似物有可能用于内质网应激相关疾病的治疗。

The unfolded protein response (UPR) has two different faces; an anti-inflammatory aspect (light side) and tissue damaging potential (dark side). Different branches of the UPR contribute to the dark and light sides following endoplasmic reticulum (ER) stress. By modulating selective arms of the UPR, it is feasible to attenuate inflammation and to inhibit tissue damage caused by ER stress. 3’-Deoxyadenosineand 4-phenylbutyric acid analogues may be potentially useful for the treatment of ER stress-related disorders.