Nanobioprobes for Multimodal Imaging Diagnostics of Cancer in Experimental Animals

本实验的目的是阐明该探针是否适用于荧光/磁共振联合成像的结肠癌早期诊断。我们采用两种多模态量子点探针（qd探针）对实验动物进行肿瘤成像，分别采用荧光成像和磁共振成像。将qd探针（用碳二亚胺与PEG和B72.3偶联）注射到小鼠尾部。7T-MRI和光学成像可以在早期显示肿瘤。我们的研究已经在同行评议的期刊和科学会议上发表。

The purpose of these experiments is to clarify whether this probe is appropriate for early diagnostics of colon cancer using combined fluorescence/MR imaging. We applied two multimodal quantum dot probes (QD-probe) for cancer imaging in experimental animals, using fluorescent imaging and magnetic resonance imaging. QD-probe (conjugated with PEG and B72.3 using carbodiimide) was injected into the tail vain of the mouse. 7T-MRI and optical imaging allows visualization of the tumor in the early stage. Our research has been reported as manuscripts in peer-reviewed journals and presentations on scientific conferences.