An examination of biological rhythms based on hormone secretion in saliva as parameters of morning motivation or fatigue

在日本，患有心身疾病的青少年通常有时代性问题。在目前的研究中，15名年龄在21岁到22岁之间的健康学生被检测了基于褪黑素和生长激素分泌模式的时型的生理参数，使用荧光酶免疫分析。每天从受试者家中采集唾液样本五次。此外，受试者每天对他们的心身症状进行两次评分。与规律昼夜节律(RCR)组相比，褪黑激素(ICR)不规则昼夜节律组表现出更多的心身不适，尤其是焦虑。心身症状，特别是焦虑，可能与褪黑激素和生长激素节律有关，即使在健康的学生中，基本的生活习惯也可以改变这些节律。

Adolescent in Japan suffering from psychosomatic complaints often have chronotypic problems. In the current study, 15 healthy students between 21 and 22 years of age were examined for physiological parameters of chronotypes based on melatonin and growth hormone secretion patterns, using a fluorescence enzyme immunoassay. Salivary samples were collected from subjects at home five times each day. In addition, the subjects rated their psychosomatic symptoms twice a day. The irregular circadian rhythm of melatonin (ICR) group showed more psychosomatic complaints as compared with the regular circadian rhythm (RCR) group, especially for anxiety. Psychosomatic symptoms, especially anxiety, might be associated with melatonin and growth hormone rhythms, which can be altered by basic lifestyle habits even in healthy students.