The role of membrane phospholipids in establishment of cell polarity

在大多数真核细胞中，细胞膜由两层磷脂组成，两层磷脂组成不同。我们研究了酵母两层间磷脂转运的分子机制和作用。我们发现了一些新的因素参与磷脂转运在质膜和膜蛋白涉及的流动性的质膜。此外，F-box蛋白Rcy1被认为是内体中Drs2催化的磷脂易位和囊泡形成之间的中介。

In most eukaryotic cells, cell membranes are composed of two layers that have different composition of phospholipids. We have investigated molecular mechanisms and roles of translocation of phospholipids between two layers in yeast. We identified some novel factors involved in translocation of phospholipids in the plasma membrane and a membrane protein implicated in fluidity of the plasma membrane. Moreover, an F-box protein Rcy1 is suggested to function as a mediator between vesicle formation and translocation of phospholipids catalyzed by Drs2 in endosomes.