Biosynthes is of kasugamycin, an anti-rice blast antibiotic, in heterologous microorganisms, for the creation of hybrid antibiotics

从抗稻瘟病抗生素春雷霉素（KSM）及其类似物米诺胺霉素（MSM）的产生菌中克隆了KSM及其类似物的生物合成基因。结果发现，它们含有共同的kasugamine生物合成基因，并产生KSM和MSM异源时，通过染色体整合载体引入。此外，MSM生物合成基因的特定部分诱导未知抗生素的异源产生。这些结果似乎表明，这些生物合成基因的适当组合能够产生新的抗生素。

The biosynthetic genes of kasugamycin(KSM), anti-rice blast antibiotic, and minosaminomycin(MSM), an analogue of KSM, were cloned from their producing streptomycetes. It was found that they contained kasugamine-biosynthetic genes in common, and produced KSM and MSM heterologously when introduced via a chromosomal integration vector. In addition, specific parts of MSM biosynthetic genes induced heterologous production of unknown antibiotic(s). These results seem to suggest that suitable combination of these biosynthetic genes enables to produce new antibiotic(s).