Structure and function of streptococcal system for heparin degradation/import and its involvement in infectious diseases

致病性链球菌产生不饱和葡萄糖醛基水解酶（UGL）和负责完全降解糖胺聚糖的多糖裂解酶，链球菌的UGL偏爱硫酸酸化底物。这表明底物特异性是可行的细菌感染通过降解哺乳动物细胞外基质与硫酸盐基团。UGL中的基序“R-//- sxx (S)xK”是硫酸盐底物降解的先决条件。

Pathogenic streptococci produce unsaturated glucuronyl hydrolase (UGL) together with polysaccharide lyase responsible for completely degrading glycosaminoglycans, and the streptococcal UGLs prefer sulfated substrates. This suggests that the substrate specificity is feasible for bacterial infection through degradation of mammalian extracellular matrices with sulfate groups. The motif "R-//-Sxx(S)xK" in UGL is prerequisite for degradation of sulfated substrates.