Hypoglycemic Effects of Compounds from Crude Drugs focused on the participation of Monoamine Neurotransmitters in Blood Glucose Regulation

Shokyo和Kankyo的磺化衍生物具有降糖作用，其机制可能是抑制糖水解酶的活性。此外，连续5周反复给药6- gingesulfacid，在KK-A^y小鼠的整个实验期间均显示出持续的降糖作用。同时，6-GS的降糖作用与脑血清素水平升高相关。提示血清葡萄糖浓度对KK-A^y小鼠脑单胺类神经递质代谢有影响。

The sulfonated derivatives from Shokyo and Kankyo have a glucose-lowering effect on loading sugar, which may be based on inhibition of the activity of saccharide hydrolyzing enzyme. Also, the repeated administration of 6-gingesulfonic acid for five weeks showed continuous hypoglycemic effects throughout the experimental periods in KK-A^y mice. Concomitantly, the hypoglycemic effects of 6-GS were correlated with the increased brain serotonin levels. These findings suggest that serum glucose concentrations influence on the brain monoamine neurotransmitters metabolism in KK-A^y mice.