A thoroughgoing investigation of structure of chondroitin sulfate stimulating on immunosystem.

以二氧化钛为光解体系，在370~430 nm波长范围内，对市售硫酸软骨素进行解聚，分离得到各低聚糖，并用色谱和仪器技术对其进行了表征。此外，将纯化的硫酸软骨素低聚糖用三氧化硫-吡啶络合物进行化学磺化，为建立硫酸软骨素低聚体文库提供了条件。此外，将这些寡糖应用于口服硫酸软骨素的免疫刺激作用的研究中，找到了能够通过小鼠消化系统吸收的低聚糖的确切大小。

Commercially available chondroitin sulfate was depolymerized by photolytic degradation system using titanium dioxide under 370～430 nm, and each oligosaccharide has been isolated and characterized by chromatographic and instrumentational techniques. Additionally, the purified chondroitin sulfate oligosaccharides were chemically over sulfonated using sulfur trioxide-pyridine complex and supplied for establishment of chondroitin sulfate oligomer library. Furthermore, these oligosaccharides were applied for the investigation of immune stimulating effects of chondroitin sulfate administered orally and found the exact size of oligosaccharide which is able to be absorbed through digestive system of mice.