Blood Levels of n-3 Fatty Acids and the Risk of stroke and Coronary Heart Disease Among Japanese The Japan Public Health Center-Based(JPHC) Study

在日本，有一些流行病学研究，其中研究了鱼的摄入量(和n-3脂肪酸的摄入量)和冠心病的发病率和/或死亡率。这些研究的结果并不一致。一些人显示出鱼的有益作用，但另一些人则没有。在日本，没有关于血液脂肪酸组成与心血管死亡风险之间关系的大规模流行病学研究。因此，我们对日本公共卫生中心研究中的209例冠状动脉死亡及其对照(n=418)进行了嵌套式病例对照研究。用气相色谱法测定总磷脂的脂肪酸组成。我们发现在任何脂肪酸水平上都没有显著差异。如果将男性和女性结合在一起，血液脂肪酸组成对心血管死亡的影响似乎很小。

In Japan there have been a few epidemiological studies in which fish consumption(and n-3 fatty acid intake) and morbidity and/or mortality of coronary disease were studied. The results of those studies are not consistent. Some showed beneficial effects of fish, but others did not. In Japan, no there are no large-scale epidemiological studies on the relationship between blood fatty acid composition and the risk of cardiovascular death. We, therefore, conducted a nested case-control study with 209 coronary deaths and their controls(n=418) from the Japan Public Health Center-Based Study. The fatty acid composition of the total phospholipid fraction was measured by gas-chromatography. We found no significant difference in any fatty acid level. If both men and women are combined, there appears to be little influence of blood fatty acid composition on cardiovascular deaths.