Differences of the effect of colonic carcinogenesis by various kinds of fatty acids

我们研究了不同膳食脂肪是否影响氮氧甲烷处理大鼠结肠粘膜生长和肿瘤发生。给大鼠补充10%的玉米、橄榄油、牛肉和鱼油，持续44周。长期食用玉米油和牛油增加肿瘤发病率，BrdU掺入增加。相比之下，橄榄油和鱼油都能抑制它们。牛油喂养的大鼠的隐窝顶部经常观察到brdu结合的细胞。长期高摄入玉米油和牛脂可促进细胞增殖，调节增殖细胞的分布，可能与促进结肠肿瘤发生有关。

We investigated whether various dietary fats affected the colon mucosal growth and tumorigenesis in azoxymethane-treated rats. Rats were supplemented with 10% corn, olive, beef, and fish oil for 44 weeks. Long-term dietary corn oil and beef tallow increased tumor incidence with increased BrdU incorporation. In contrast, both olive and fish oil inhibited them. BrdU-incorporated cells were often observed at tops of crypts in rats fed with beef tallow. Long-term high intake of corn oil and beef tallow enhanced cell proliferation and modulated distribution of proliferating cells, which might contribute to promoting effect in colon tumorigenesis.