Analysis of the molecular mechanism regulating target gene selection

在脊椎动物的发育过程中，同一个信号分子经常重复表达，并在每个时间和地点发挥重要作用。这意味着在每种情况下，相同的信号可以不同地调节基因的表达。这种基因表达的差异控制可能是由细胞对信号的反应能力差异引起的。在本研究中，我们将分析斑马鱼基因表达差异控制缺陷突变体的表型，并确定其相关基因，并试图了解差异能力的分子机制。

During vertebrate development, the same signaling molecule is often expressed repeatedly and plays an important role in each time and place. This means the same signal can differently regulate the expression of genes in each case. This differential control of gene expression is probably caused by differential competence of the cells in response to signals. In this research, we will analyze the phenotype of zebrafish mutants which are defective for the differential control of gene expression and identify their responsible genes, and try to understand the molecular mechanism underlying the differential competence.