Evolutionary conserved mechanisms of cell movements in metazoans : insights from the ctenophore Brachyury

注射的RNA编码的显性干扰构建体的M1 Bra，短尾（Bra）直系同源的栉水母Mnemiopsis leidyi，到非洲爪蟾胚胎显示，MlBra可以调节非洲爪蟾原肠胚形成以相同的方式作为内源性非洲爪蟾Bra（Xbra），这表明在细胞运动中的作用的Bra是保守的物种。此外，在非洲爪蟾胚胎中的微阵列分析表明，Delta-Notch信号成分和嘌呤核苷磷酸化酶基因可能在Bra下游发挥作用。

Injection of RNA encoding a dominant-interfering construct of M1Bra, a Brachyury (Bra) ortholog of the ctenophore Mnemiopsis leidyi, into Xenopus embryos revealed that MlBra could regulate Xenopus gastrulation in the same way as the endogenous Xenopus Bra (Xbra), suggesting that the role of Bra in cell movements is conserved over the species. In addition, microarray analyses in Xenopus embryos suggested that Delta-Notch signaling components and the purine-nucleoside phosphorylase gene may function downstream of Bra.