The bacterial controls using antimicrobial peptides from complement components of fish

结果表明，鲤鱼C3同种型（C3-Q1）C3 a区部分氨基酸序列（KVFLECCNLMKTHKNMKTE）所对应的合成肽具有抗菌活性，对革兰氏阴性菌大肠杆菌有抗菌作用。（XL 1-Blue mrf和O 157：H7（VT 1和VT 2））和肠炎沙门氏菌。我们成功地增强了抗菌活性，通过部分取代上述序列的氨基酸。然而，发现抗菌活性的增强导致高细胞毒活性。在此基础上，我们希望通过本研究的观察，创造出副作用小的抗菌肽。

Our results revealed that the synthetic peptide corresponding to partial amino acid sequence (KVFLECCNLMKTHKNMKTE) of C3a region of carp C3 isotype (C3-Q1) was antibacterial, and acted on Gram-negative bacteria, Escherichia coli. (XL1-Blue mrf and O157:H7 (VT1 and VT2)) and S.Enteritidis. We successfully enhanced antibacterial activity, by partially replacing amino acids of above-mentioned sequence. However, it was found that enhancement of antibacterial activity led to high cytotoxic activity. Hereafter, we aim to create antimicrobial peptides with low side effects on the basis of observation in this study.