Synthesis of new seco-steroidal compounds, their use for steroidal biological evaluation, and development of new drug candidates

在这个项目中，我通过合成化学修饰的方法合成并稳定分离了14-epi-维生素D3原类似物作为新的仲甾体化合物。利用这些新的类似物，我评估了它们的生物学特性，并发现了一种新的骨质疏松症药物先导化合物。同时，我也有了初步的结果来评估它们的非基因组作用。通过去除19-甲基，我发现了从维生素D3原到快胆固醇骨架的异构化，这可能是一种新的候选药物。

In this project, I have synthesized and stably isolated the 14-epi-previtamin D3 analogs as new seco-steroidal compounds by synthetic chemical modification. Using these new analogs, I evaluated their biological properties, and have found a new lead compound for osteoporosis drug. Also, I was able to have preliminary results for the evaluation of their nongenomic action. By the removal of 19-methyl group, I have discovered the isomerization from previtamin D3 to tachysterol skeleton, which could be a new drug candidate.