Approach to PET cancer screening : developments of low molecule probe tagged gallium-68 and carbon-11labeling method

我关注了正电子发射的放射性核素，特别是镓-68和碳-11，并基于高速反应，利用不稳定的化学物质如芳烃和自由基作为标签，开发了以下反应。此外，我还开发了利用光催化剂捕获CO_2的氧化还原反应。首先，为了开发镓-68探针，我在无金属条件下研究了基于芳烃的huisgen型反应，并以优异的收率得到了所需的苯三唑。我还报道了[2+2]型反应，在甲酰胺的C=O π键中插入芳炔，随后用二烷基锌捕获苯并辛烯中间体的过程。此外，在温和的条件下，我报道了通过插入DMF的π键导致铬、香豆素和杂蒽的多组分偶联反应。此外，我报道了级联加成-环化-捕获反应，涉及亲核自由基的不利不匹配相互作用，以及对映选择性的控制。报道了多晶TiO_2 （P25）在芳香酮加氢反应中的应用。

I paid attention to the positron-emitting radionuclide, especially gallium-68 and carbon-11, and developed the following reactions using an unstable chemical species such as aryne and radical for the label based on high-speed reactions. In addition, I developed the oxidation-reduction reaction using the photocatalyst for capture of CO_2.First, to develop gallium-68 probe, I studied aryne based Huisgen-type reaction under the metal-free condition and desired benztriazole was obtained in excellent yield. I also reported the [2+2] type reaction, insertion of aryne into the C=O π-bond of formamides, and the subsequent trapping process of the benzoxetene intermediate with dialkylzincs. In addition, under mild condition, I reported the multi-component coupling reaction leading chromenes, coumarins and xanthenes via the insertion into π-bond of DMF. Moreover, I reported the cascade addition-cyclization-trapping reaction involving the unfavorable mismatched interaction of nucleophilic radicals, together with the control of enantioselectivities. And I reported the results of experiments to prove the utility of the polycrystalline TiO_2 (P25) in the hydrogenation of aromatic ketones.