Optimization of nasal administering conditions with the formulation development.

为建立优化鼻用制剂的评价体系，考察了该制剂经鼻给药后的药物吸收情况。药物在鼻腔内的停留与粉末在鼻腔内溶出的平衡是决定药物鼻腔吸收的重要因素。这表明通过控制粉末制剂的鼻腔停留时间来改善鼻吸收的可行性。另一方面，澄清了药物的跨细胞渗透性取决于用于体外研究的细胞的来源。这一发现将对以往建立的鼻腔药物吸收评价体系进行更新和完善。

In order to establish the evaluation system to optimize the nasal formulation, drug absorption from the powder formulations following nasal administration was investigated. The balance of the nasal residence of the drug and the dissolution from powder in the nasal cavity was an important factor to determine the nasal drug absorption. This finding suggested the feasibility that the nasal absorption is improved by controlling the nasal residence time of powder formulation. On the other hand, it was clarified that the transcellular permeability of the drug is dependent on the origin of the cell used for in vitro study. This finding would lead to renewing and improving the estimation system for nasal drug absorption, which had been previously established.