WANIAR4 ( M) Development of the animal model for postpartum psychosis and the elucidation of pathogenic mechanisms through estrogen action

我们发现，与间情未孕雌性大鼠相比，产后3周的未孕大鼠在高架十字迷宫（EP）和强迫游泳（FS）测试中表现出增加的焦虑和抑郁行为。雌激素选择性激动剂和雌激素在产后3周的EP和FS试验中显示出抗焦虑和抗抑郁作用，每天皮下注射一次，持续4天。此外，我们发现了一个显着的变化，TrkB和BDNF（脑源性神经营养因子）受体的表达，并在所产生的细胞内信号的3周postpartums。这提出了一种可能性，即通过ER α刺激的神经营养因子信号传导的变化与焦虑和抑郁样行为相关。结论：建立了产后精神病和产后抑郁症的动物模型，可用于开发ER α激动剂的创新药物。

We found that primiparous rats at 3 weeks-postpartum showed increased anxiety and depressive behaviors in elevated plus maze (EP) and forced swimming (FS) tests, compared with diestrus nulliparous females. ERa-selective agonist and estrogen displayed anxiolytic and antidepressant effects in EP and FS tests at 3 weeks-postpartum after subcutaneous injection once daily for 4 days. Furthermore, we found a marked alteration in the expression of TrkB and BDNF (brain-derived neurotrophic factor) receptors, and in resultant intracellular signaling of the 3 weeks-postpartums. This raises a possibility that changes of neurotrophin signaling via ERa stimulation are associated with anxiety and depression-like behaviors. In couclusion, we identified an animal model of postpartum psychosis and postpartum depression, which could be employed to develop innovative drugs of ERa stimulant for these diseases.