Effects of oral exposure to pesticide residues in allergic diseases during early childhood.

农药残留是一种环境污染物，可能会增加过敏原的效力，从而在变态反应性疾病的发生和发展中发挥作用。在小鼠模型中，我们确定了儿童早期口服农药是否会影响包括特应性皮炎和过敏性呼吸道炎症在内的过敏性疾病。无论是雄性还是雌性小鼠，接触杀虫剂都没有显示出对特应性皮炎样皮肤损害的显著增强作用。另一方面，γ-六六六(六六六)加重了雌性小鼠与过敏原相关的呼吸道炎症，但不是雄性小鼠。综上所述，儿童早期口服农药暴露可能在疾病类型和/或性别差异方面显示出不同的影响。

Pesticide residues, ones of environmental pollutants, may increase the potency of allergens and thereby play a role in the onset and progression of allergic diseases. We determined whether oral exposure to pesticides in early childhood affect allergic diseases including atopic dermatitis and allergic airway inflammation in murine model. Exposure to pesticides did not show significant enhancing effects in atopic dermatitis-like skin lesions either male or female mice. On the other hand, γ- benzene hexachloride (BHC) aggravated allergen-related airway inflammation in female mice, but not male mice. Taken together, oral exposure to pesticides in early childhood can show various effects in the type of disorders and/or sex differences.