Regulation of VEGF expression by PPAR in human lung cancer cells

糖尿病患者使用噻唑烷二酮（TZD）与肺癌风险降低特别相关。由于胶原蛋白XVIII是肺癌患者预后的最强预测因子之一，我们研究了TZD对人非小细胞肺癌（NSCLC）细胞中胶原蛋白XVIII表达的影响。本研究结果首次提示TZDs可降低NSCLC中胶原XVIII的表达，这可能有助于我们理解TZDs具有化学预防作用的机制。

Thiazolidinedione (TZD) use in patients with diabetes was specifically associated with reduced risk of lung cancer. Since collagen XVIII is one of the strongest predictors of outcome in patients with lung cancer, we examined the effects of TZD on expression of collagen XVIII in human non-small lung cancer (NSCLC) cells. The present results results suggest for the first time that TZDs reduced expression of collagen XVIII in NSCLC, which may help us understand the mechanism why TZDs use has chemopreventive action.