Clinical research for disease mechanisms associated with TFL gene dysfunction in malignant lymphoid tumors

我们最近发现了一个具有类似ccch型锌指结构域的新基因，作为一个可能的肿瘤抑制基因，该基因参与了人类转化滤泡性淋巴瘤的隐性断点易位。为了阐明该基因的临床意义，我们分析了84例淋巴瘤患者的基因缺陷。11例患者（15.3%）至少丢失一个等位基因。TFL蛋白抑制细胞生长，诱导细胞凋亡。至于其亚细胞定位，它定位于称为p体的细胞质颗粒中。TFL对淋巴细胞增殖的抑制活性突出了TFL作为白血病和/或淋巴瘤治疗靶点的潜在效用。

We recently identified a novel gene with a similar CCCH-type zinc finger domain as a possible tumor suppressor gene that is involved in a cryptic breakpoint translocation found in human transformed follicular lymphoma. To clarify clinical significance for the gene, we analyzed the gene defect of 84 lymphoma patients. Eleven patients (15.3%) lose at least one allele. TFL protein inhibited cell growth and provoked apoptosis. As for its subcellular localization, it localized in the cytoplasmic granules called P-bodies. The inhibitory activity of TFL for lymphocyte proliferation highlights the potential utility of TFL as therapeutic targets for leukemia and/or lymphoma.