Intracellular oxidation potential of oligodendrocyte in periventricular leukomalacia

脑室周围白质软化症是一种出生体重极低的少突胶质细胞病变。在对大鼠脑内少突胶质细胞系进行初始化后进行分化，给它们施加各种细胞因子。细胞因子的组合减少了活细胞。细胞因子延缓了细胞的分化。我们根据负荷测量了细胞中产生的氧化应激。特别是，随着IL-6负荷的增加，过氧化氢含量呈剂量依赖性增加。当我们把细胞因子放在一起时，过氧化氢的产生接受了更早的时间。

Periventricular leukomalacia is a lesion of oligodendrocyte in very low birth weight. Differentiating after having initialized cell line of a rat brain oligodendrocyte, we burdened them various kinds of cytokine. Combinations of cytokines decreased viable cell. Cytokines delayed the differentiation of the cells. We measured oxidative stress produced in a cell by load. In particular, hydrogen peroxides increased in dose dependence with IL-6 load. The production of a hydrogen peroxide accepted an earlier timing when we put cytokine together.