Study of optimization of extracorporeal circulation in open heart surgery on diminished immune function

在本研究中，为了阐明体外循环对免疫系统的影响，我重点研究了淋巴细胞的功能，并检测了淋巴细胞母细胞转化能力的变化。经植物血凝素(PHA)处理后，接触膜式氧合器体外循环回路的乳突状转化能力低于未接触膜式氧合器体外循环回路的乳突状转化能力。封闭式体外循环与开放式体外循环能力差异无统计学意义。不加氧气组和有氧气组的体外循环能力也无明显差异。

In the present study, to elucidate the effects of extracorporeal circulation in open heart surgery on the immune system, I focused on the function of lymphocytes and examined the changes in the ability of lymphocyte blastoid transformation. After the treatment with Phytohemagglutinin(PHA), ability of lastoid transformation in contact with the extracorporeal circulation circuit with membrane oxygenator was lower than the ability in contact with extracorporeal circulation circuit without membrane oxygenator. There was no significant difference of the ability between the closed extracorporeal circulation circuit and the opened extracorporeal circulation circuit. And there was no significant difference of the ability between the extracorporeal circulation circuit without oxygenator gas and the extracorporeal circulation circuit with oxygenator gas too.