Development of human lung cancer model using NOD/SCID/γC null mouse

我们研究了一种非侵入性的方法来评估肿瘤在小鼠肺中的生长。采用人肺癌细胞株（A549）尾静脉注射法建立了NOD/SCID/γcnull（NOG）小鼠非小细胞肺癌（NSCLC）异种移植模型。MRI（磁共振成像）检测到的肺实变与肺内肿瘤生长平行恶化。MRI可用于无创性评价肿瘤在小鼠肺中的生长。

We studied a noninvasive method to evaluate tumor growth in the lung of mice. Xenotransplant model of lung cancer (NSCLC) using NOD/SCID/γcnull (NOG) mice was developed by tail vain injection of human lung cancer cell line (A549). The lung consolidation detected by MRI (magnetic resonace imageing) deteriorated in parallel with intrapulmonary tumor growth. MRI may be useful to noninvasively evaluate tumor growth in lung of mice.