Protective Actions of Adiponectin on Cerebral Ischemia-reperfusion Injury.

脂联素是一种脂源性血浆蛋白，对心血管疾病具有有益作用。低水平血浆脂联素与缺血性卒中后死亡率增加相关。然而，脂联素在缺血性卒中中的因果作用尚不清楚。与WT小鼠相比，APN-KO小鼠在缺血-再灌注后表现出扩大的脑梗死和增加的神经功能缺损。相反，腺病毒介导的脂联素补充显著减少WT和APN-KO小鼠的脑梗死面积。通过激光散斑血流测量法，APN-KO小鼠在缺血期间显示脑血流量减少。这些数据为脂联素具有神经保护作用提供了新的证据。脂联素可能成为预防缺血性脑卒中的分子靶点

Adiponectin is a fat-derived plasma protein that has beneficial actions on cardiovascular disorders. Low level of plasma adiponectin is associated with increased mortality following ischemic stroke. However, the causal role of adiponectin in ischemic stroke is unknown. APN-KO mice exhibited enlarged brain infarction and increased neurological deficits following ischemia-reperfusion compared with WT mice. Conversely, adenovirus-mediated supplementation of adiponectin significantly reduced cerebral infarct size in WT and APN-KO mice. APN-KO mice showed decreased cerebral blood flow during ischemia by laser speckle flowmetry methods. These data provide a novel evidence that adiponectin exerts a cerebroprotective action. Adiponectin could represent a molecular target for the prevention of ischemic stroke