Examination of negative regulation of cytokine signals in endometriosis

大约10%的育龄妇女会发生子宫内膜异位症。其病因尚不清楚。本研究检测了两条信号通路(JAK-STAT通路和RAS-MAP通路)在子宫内膜异位症中的激活情况。对50例子宫内膜异位症患者和50例对照组进行检查。在15例子宫内膜异位症患者中，STAT3被激活。年龄、非甾体抗炎药的使用、作用时间与STAT3的激活无关。Gn-RHA组STAT3活性较术前略低。MAP通路无明显趋势性改变。

Endometriosis occurs in about 10% of reproductive age women. The etiology of it is not clearly defined. In this study we examined the activation of two signal pathway (JAK-STAT pathway and, RAS-MAP pathway) in endometriosis. 50 of endometriosis case and 50 of control cases were examined. In 15 endometriosis patients STAT3 was activated. The age, use of NSAIDs, affection period were not related to the activation of STAT3. The activity of STAT3 was slightly lower in a preoperative Gn-RHa administrated group. No obvious tendency was fined in MAP pathway.