The mechanism of the enhanced sensitivityof anticancer drug andradioactive ray by the cox-2 inhibitor in oral squamous cell carcinoma

人们注意到，炎症组织中诱导了环加氧酶（考克斯）的表达，另一方面，近年来研究表明，考克斯在肿瘤发生中发挥着重要作用，并且在许多恶性肿瘤中诱导了考克斯-2的高表达。在本研究中，考克斯-2选择性抑制剂有增强抗癌药物和放射线对人口腔鳞癌细胞系的作用的趋势。提示选择性考克斯-2抑制剂可能有助于提高口腔癌的治疗效果。

It's noted that expression of cyclooxygenase(COX) is induced in the inflammatory tissue, on the other hand, it is suggested that COX plays a significant role in oncogenesis during recent years, and high expression of COX-2 is induced in a number of the malignant neoplasm. In this study, the COX-2 selective inhibitor had tended to enhance the effect of anticancer drug and radiation against the human oral squamous carcinoma cell line. These results indicate that the COX-2 selective inhibitor may contribute to improving effect of oral cancer therapy.