Regulation of hematopoiesis by dendritic cells

树突状细胞(DC)通过产生多种细胞因子来调节淋巴细胞功能，从而维持免疫系统的动态平衡。这一调节系统的崩溃促进了免疫紊乱，如感染受损、对免疫刺激反应过度和自身免疫性疾病。DC可能影响造血干细胞的分化和增殖，但很大一部分仍不清楚。这项研究至少部分揭示了DC吞噬自身造血细胞的机制和生理作用，以及微生物衍生核酸(如DNA和RNA)的影响。

Dendritic cells (DCs) maintain the homeostasis of immunologic system by regulating lymphocyte functions through the production of various cytokines. The collapse of this regulatory system promotes immunologic disorders such as compromised infection, overresponse to immunologic stimuli and autoimmune diseases. DCs might influence differentiation and proliferation of hematopoietic stem cells, however, a large part has remained unclear. This study, at least in part, revealed the mechanism and the physiological role of DCs phagocytosing self-hematopoietic cells and the influence of microbe-derived nucleic acid such as DNA and RNA.