Involvement of opioid system in nicotine and alcohol dependence

在本研究中，我们探讨了内源性阿片系统在尼古丁或酒精诱导的身体依赖中的作用。阿片受体拮抗剂纳洛酮治疗引起小鼠戒断症状，每天两次给予尼古丁，持续5-9天。阿片受体拮抗剂纳曲酮可抑制尼古丁依赖。另一方面，给予含乙醇（1%）水的小鼠纳洛酮治疗引起戒断症状。这些结果表明，内源性阿片系统在尼古丁或酒精诱导的身体依赖中起重要作用。

In this study, we investigated the role of endogenous opioid system in physical dependence induced by nicotine or alcohol. Treatment of opioid receptor antagonist, naloxone caused withdrawal symptoms in mice administered nicotine twice a day for 5-9 days. Nicotine dependence was suppressed by opioid receptor antagonist, naltrexone. On the other hand, treatment of naloxone caused withdrawal symptoms in mice given water including ethanol (1%). These results suggest that endogenous opioid system plays an important role in physical dependence induced by nicotine or alcohol.