Involvement of interaction between RNA and protein in neurodegenerative mechanisms in dementia

为了阐明RNA和蛋白质之间的相互作用在神经退行性过程中的作用，我们通过氧化应激增加了核素毒性应激，揭示了tau的磷酸化和JNK和p38 MAPK的激活。TLR-3，一种可以结合双链RNA的先天免疫受体，也在疾病脑中进行了研究，包括阿尔茨海默病和淀粉样蛋白转基因小鼠Tg2576。TLR-3在阿尔茨海默病和Tg2576中表达显著升高，且TLR-3阳性细胞分布在淀粉样斑块内部和周围。在这些神经退行性过程中，rRNA的氧化或从死细胞中释放RNA可能参与其中。

To elucidate involvement of interaction between RNA and protein in neurodegenerative processes, ribotoxic stress was added by oxidative stress, and phosphorylation of tau and activation of JNK and p38 MAPK were revealed. And, TLR-3, an innate immune receptor that can bind to double stranded RNA, was also investigated in disease brain, including Alzheimer disease and amyloid-transgenic mice Tg2576. Expression of TLR-3 was significantly increased in Alzheimer disease and Tg2576, and TLR-3 positive cells were distributed in and around amyloid plaques. In these neurodegenerative processes, oxidation of rRNA or release of RNA from dead cells, might be involved.