Analysis on invasion and metastasis of lung adenocarcinomas with micropapillary pattern.

为分析微乳头状型(MPP)肺腺癌与血管内皮生长因子(VEGF)的关系，收集517例肺癌手术切除标本并进行临床病理研究。MPP阳性肺癌预后差，血管侵犯频繁，淋巴结转移频繁。免疫组织化学显示，血管内皮生长因子C和R3在MPP部分呈强阳性表达。通过对小鼠模型的分析，认为VEGFR-1和VEGFR-2在间质组织的肿瘤进展中起重要作用。

To analyze the relationship between lung adenocarcinomas with micropapillary pattern (MPP) and vascular endothelial growth factors (VEGF), 517 cases of resected lung cancers were collected and clinic-pathologic study was performed. MPP- positive lung cancers revealed poor prognosis, frequent vascular invasion, and frequent lymph node metastasis. Immunohistochemically, VEGF-C and R3 strongly expressed in MPP portions. By the analysis on mice models, it was considered that VEGFR-1 and 2 plays an important role in tumor progression on the stromal tissue.