A examination of KGF seat to prevent bronchpleural fistula.

气管创面局部应用KGF不能促进气管软骨的愈合。另一方面，气管内给予KGF可增强三叶切除后大鼠肺上皮细胞的增殖。在剩余肺中气管内给予KGF可显著增加肺泡细胞的PCNA。高剂量单次注射和低剂量每日注射均有效。我们的研究结果表明，气管内给予KGF可显著增强三叶切除后剩余肺代偿性生长的肺上皮增殖。

Local administration of KGF to trachea wound could not enhance the healing of trachea cartilage. On the other hand, intratraheal administration of KGF enhanced pulmonary epithelial proliferation in post-trilobectomy rat lung. Intratracheal administration of KGF in the remaining lung significantly augmented PCNA of alveolar cell. High dose single injection and low dose daily injection were so effective. Our results implicate that Intratracheal administration of KGF significantly augmented lung epithelial proliferation in compensatory growth in the remaining lung after trilobectomy in rats.