Clarification of the three-dimensional structure of vascular malformations by objective differentiation between blood vessels and lymphatic vessels, and its clinical application

我们使用大量的血管内皮细胞免疫组化标记物，包括我们最近开发的LYVE-1抗体，对血管畸形的病态血管进行免疫组化检查。本研究表明，在血管畸形中表达了多种类型的免疫组织化学标记物，这些标记物可以归类为血管畸形的同一类别，如淋巴管畸形或静脉畸形。这表明它们遵循不同的发病机制。此外，免疫组织化学方法更容易正确诊断各种微血管的病理。研究表明，该方法有助于准确诊断早期消化道癌的小淋巴管微侵，并有助于确定冠状动脉疾病的适当治疗。

Immunohistochemical examinations were performed on the morbid vessels of vascular malformations using bountiful immunohistochemical markers of vascular endothelial cells including LYVE-1 antibodies, which we had recently developed. This study demonstrated that various patterns of immunohistochemical markers were expressed in vascular malformations which could be classified in the same category of vascular malformations such as either lymphatic vessel malformations or venous malformations. This suggests that they follow a different pathogenesis. In addition, the immunohistochemical method has made it easier to properly diagnosis the pathology of various microvessels. It has been demonstrated that this method is useful for accurate diagnosis of microinvasion into the small lymph vessels during the early stages of gastroenterological carcinoma and in determining the proper management of coronary disorders.