Reconstruction of Metabolic Network for Extracting Design Principles of Natural Products

天然化合物的设计需要提取化合物结构中记录的设计信息，并在系统重构代谢网络的基础上建立设计框架。我们研究了表达天然化合物、重构代谢网络信息和分析代谢网络的方法。本研究提出的系统的化合物表示方法比传统的方法更好地反映了生物合成信息，可以为任何天然化合物提供设计路线。

It is necessary for the design of a natural compound to extract design information recorded in the structure of the compound, and to build a design frame based on a systematic reconstruction of metabolic network. We examined the way to express natural compounds, to reconstruct metabolic network information, and to analyze the metabolic network. The systematic way to represent compounds proposed in this study resulted in better reflecting biosynthetic information than conventional methods, which could propose the design route for any natural compound.