Development of prophylactic therapy against sepsis and hepatic failure in rat short bowel models managed with total parenteral nutrition

采用大肠癌切除法建立大鼠短肠模型。采用全肠外营养喂养动物，观察给予神经肽、bombesin对全肠外营养诱导的胆汁淤积性肝功能障碍是否有良好的作用。在这项调查中，长期维持全肠外营养遇到了技术上的困难。因此，bombesin可以抑制肠道黏膜细菌的移位，改善胆汁淤积性肝功能障碍的程度。

The rat short bowel model was established by massive intestinal resection. The animals were managed with total parenteral nutrition and were investigated whether administration of neuropeptide, bombesin, had favorable effect against cholestatic liver dysfunction induced by total parenteral nutrition. During this investigation, technical difficulty was encountered for the maintenance of long-term total parenteral nutrition.As a result, bombesin could suppress bacterial translocation from intestinal mucosa and ameliorate the extent of cholestatic liver dysfunction.