The role of TFE3, a metabolism-related transcription factor, in skeletal muscles.

在本研究中，我们利用在肌肉中过表达TFE3的转基因小鼠，研究了TFE3在骨骼肌（能量代谢的主要器官）中的作用。在TFE3转基因肌肉中，糖原储存比野生型多2倍以上，这与参与葡萄糖代谢的基因上调有关，特别是GLUT4、HK2和GYS。因此，该转基因模型的运动耐力增强。此外，转基因小鼠的胰岛素敏感性增强，并在4周运动训练后表现出更好的改善。TFE3在调节骨骼肌内代谢基因和葡萄糖代谢方面的潜在作用表明，它可能用于治疗代谢性疾病，以及提高运动耐力。

In this study, we investigated the roles of TFE3 in skeletal muscle, the main organ for energy metabolism, using transgenic mice overexpressing TFE3 in muscles. In TFE3 transgenic muscle, glycogen stores were more than 2-fold than wild-type, and this was associated with an upregulation of genes involved in glucose metabolism, specifically GLUT4, HK2 and GYS. Consequently, exercise endurance capacity was enhanced in this transgenic model. Furthermore, insulin sensitivity was enhanced in transgenic mice, and exhibited better improvement after 4 weeks of exercise training.These potential roles of TFE3 in regulating metabolic genes and glucose metabolism within skeletal muscle suggests that it may be used for treating metabolic diseases, as well as increasing endurance in sport.