Development of a diabetes risk profile using a urinary biomarker and its application in the assessment of nutrient status and exercise levels.

及早发现糖尿病前期个体并随后改变生活方式是预防糖尿病的重要策略。我们开发了一种利用尿液和干滤纸血样检测糖尿病前期的新技术。我们将这项新技术应用于营养状况和运动水平的评估。糖尿病患者尿液中的可溶性胰岛素受体、抵抗素和胰岛素显著增加。因此，结合使用这些尿液生物标志物来评估糖尿病风险是可能的。此外，我们还表明，积极的生活方式改变会改善这些生物标志物，包括增加锻炼和摄入膳食纤维。

The early detection of individuals with pre-diabetes and the subsequent modification of lifestyle is an important strategy in the prevention of diabetes. We have developed a new technique of detecting pre-diabetes using urine and a dry filter paper blood sample. We applied this novel technique to the assessment of nutrient status and exercise levels.Urinary soluble insulin receptor, resistin, and insulin were significantly increased in diabetic patients. Thus, it is possible to assess diabetes risk using a combination of these urinary biomarkers. In addition, we showed that these biomarkers were improved by positive lifestyle changes, including an increase in exercise and consumption of dietary fiber.