Exploration of new antitoxic compounds neutralizing ciguatera fish poisoning from some southern medicinal plants

雪卡毒素鱼中毒（CFP）是一种因食用被有毒聚醚化合物、雪卡毒素（CTXs）和maitotoxin（MTX）污染的热带和亚热带珊瑚鱼而引起的鱼类中毒。Garrec等人报道了一些南方药用植物的提取物，传统上用于治疗CFP，可以防止CTX或brevetoxin（BTX）产生的体外神经毒性。本文采用体外神经毒性实验，对从南方多种药用植物中分离得到的CFP抗毒新化合物进行了研究。

Ciguatera fish poisoning(CFP) is an ichthyosarcotoxism caused by the consumption of tropical and subtropical coral fish contaminated with toxic polyether compounds, ciguatoxins(CTXs) and maitotoxin(MTX). Garrec et al. have reported that the extracts of some southern medicinal plants, traditionally used to treat CFP, to prevent in vitro neurotoxicity produced by CTX or brevetoxin(BTX). Here, we studied new CFP antitoxic compounds isolated from verious southern medicinal plants by using in vitro neurotoxicity assay.