Functional of a brain-specific mucin-type carbohydrate glycosyltransferase involved in neural development and apoptosis

本研究的目的是阐明粘蛋白型碳水化合物和糖基转移酶参与其生物合成在神经发育中的作用。我们研究了脑特异性同工酶WBSCR17和粘蛋白型碳水化合物在小鼠胚胎癌P19细胞（可分化为神经细胞）和人胚肾HEK293T细胞中的功能。还检测了WBSCR17在斑马鱼神经分化中的作用。通过这些研究，我们阐明了WBCSR17参与神经发育和细胞膜运输。

The purpose of this study is to clarify the roles of mucin-type carbohydrates and glycosyltransferases involved in their biosynthesis in neural development. We investigated the functions of WBSCR17, a brain-specific isozyme, and mucin-type carbohydrates in mouse embryonic carcinoma P19 cells, which can differentiate into neural cells, and human embryonic kidney HEK293T cells. Also the roles of WBSCR17 in neural differentiation in zebrafish were examined. Through these studies, we elucidated that WBCSR17 is involved in the neural development and membrane trafficking in the cells.