Effect of lipid peroxidation on allergic reaction

采用体外培养细胞，研究了由活性氧生理性产生的脂质氢过氧化物对过敏反应的影响。对与过敏反应有关的白细胞肥大细胞系进行人工培养和刺激。脂质过氧化氢分解产物4-羟基-2-壬烯醛促进了肥大细胞释放组胺等化学介质。这表明脂质过氧化可能会恶化过敏。

Effect of lipid hydroperoxides which could be physiologically produced by reactive oxygen species on allergy reaction was investigated by using cultured cells in vitro. Mast cell line, a kind of white blood cell associated with allergy reaction was cultured and stimulated artificially. The chemical mediators such as histamine released from mast cells were facilitated by 4-hydroxy-2-nonenal, a decomposed product from lipid hydroperoxides. It suggests that lipid peroxidation might deteriorate allergy.