Discovery and Development of Antitumor Compounds from Marine Dinoflagellates

我们的抗癌新药研究工作是从甲藻Amphiddium sp.中分离得到几种细胞毒性多酮类化合物，其中包括两环内酯-2和-3以及caribenolide-I。通过对二维核磁共振波谱和MS数据等波谱数据的详细分析，确定了它们的结构。

Our investigation for new anticancer drug leads from the dinoflagellate Amphidinium sp., we have resulted in the isolation of several cytotoxic polyketide, amphirionins-2 and-3 and caribenolide-I from a marine dinoflagellate Amphidinium sp. Their structure elucidation were carried out using detailed analyses of spectroscopic data such as 2D NMR spectra and MS data.