Kinetics of Dysglycemia Induced by New Quinolone Antibiotics

加替沙星是一种氟喹诺酮类抗菌剂，经静脉给药后，通过增加血清胰岛素浓度引起大鼠低血糖。在较高的加替沙星血清浓度下，它促进组胺释放，导致血清肾上腺素浓度升高和高血糖。苯并啉诱导血清胰岛素浓度迅速升高。随着苯并啉剂量的增加，出现了更大的降糖作用。建立的药代动力学和药效学模型可以描述血药浓度、胰岛素和葡萄糖的时间过程。

Gatifloxacin, a fluoroquinolone antibacterial agent, caused hypoglycemia in rats after i. v. administration by increasing the serum concentration of insulin. At higher serum concentration of gatifloxacin, it promoted histamine release, leading to an increased serum epinephrine concentration and hyperglycemia. Cibenzoline induced a rapid increase in the serum concentration of insulin. As the cibenzoline dose was increased, a greater hypoglycemic effect occurred. The time courses of serum concentrations of cibenzoline, insulin and glucose could be described by the pharmacokinetic and pharmacodynamic model developed.