Study on the transportsome for ribavirin uptake in human erythrocyte membrane

利巴韦林引起的溶血性贫血可能是由于利巴韦林的磷酸化代谢物在细胞内大量积累所致。我们的研究表明，红细胞ROV对利巴韦林的摄取是由平衡核苷转运体1(ENT1)介导的。一方面，利巴韦林不被依赖于ATP的转运体排出体外。人的红细胞转运蛋白，如ENT1和葡萄糖转运蛋白，即使在接近0°C的极低温度下也能发挥作用。

The hemolytic anemia caused by ribavirin would be due to significant intracellular accumulation of the phosphorylated metabolites of ribavirin. Our research suggested that ribavirin uptake in ROVs of erythrocyte is mediated by equilibrative nucleoside transporter 1(ENT1). On one hand, ribavirin is not effluxed by ATP-dependent transporters. The human erythrocyte transporters such as ENT1 and glucose transporter function even at very low temperatures near 0°C.