The role of Sox13 in the signaling pathway that controls epithelial-mesenchymal interaction

头发的生长周期包括生长期、衰退期和休止期。我们利用Sox13突变小鼠研究了Sox13的作用，Sox13是参与细胞命运决定和分化的Sox转录因子家族的成员。我们发现，在头发周期中，毛囊中Sox13的表达是动态变化的，表明Sox13是一种新的头发周期制造者。阐明Sox13循环表达的机制对于理解脱发的发病机制具有重要意义。

Hair grows through the hair cycle consisting of anagen, catagen and telogen. We investigated the role of Sox13, a member of the Sox family of transcription factors that are involved in cell fate determination and differentiation, using Sox13 mutant mice. We found that Sox13 expression in hair follicle is dynamically changed during hair cycles, indicating that Sox13 is a novel hair cycle maker. Elucidation of the mechanism underlying the Sox13 cyclic expression would be important for understanding the pathogenesis of alopecia.