Role of Epac2/Rap1 signal in the regulation of insulin secretion in pancreatic-・-cells

我们已经在胰腺β细胞中寻找了cAMP/EPAC2/RAP1的下游信号，并确定了几个候选分子。我们还发现，参与肌动蛋白动力学的Rho家族GTP酶CDC42在胰腺β细胞中被cAMP/EPAC2激活，其基因敲除减少了cAMP增强的胰岛素分泌。这些结果表明，Epac2通过激活几个下游信号来介导cAMP对胰岛素分泌的增强。

We have searched for downstream signals of cAMP/Epac2/Rap1 in pancreaticβ-cells and identified several candidate molecules. We have also found that Rho family GTPase Cdc42, which is involved in actin dynamics, is activated by cAMP/Epac2 stimulation in pancreaticβ-cells and its knockdown decreases cAMP-potentiated insulin secretion. These results suggest that Epac2 mediates the potentiation of insulin secretion by cAMP through the activation of several downstream signals.