Molecular mechanisms of the aberrant metabolism of tryptophan in Alzheimer's disease

阿尔茨海默病（Alzheimer's disease， AD）是一种随着老年人口的增加而日益增多的神经退行性疾病。阿尔茨海默病的防治是一个迫切的社会问题。本研究研究了AD中吲哚胺2,3 -二氧合酶诱导色氨酸异常代谢导致神经毒素喹啉酸生成的分子机制。特别是假定的淀粉样蛋白受体。肽表达的活化巨噬细胞浸润到淀粉样斑块试图表征。

Alzheimer's disease(AD) is an increasing neurodegenerative disease with growing elderly population. Prevention and treatment of AD is an urgent social issue. In this study, molecular mechanisms of the aberrant metabolism of tryptophan via induction of indoleamine 2, 3-dioxygnase in AD, which leads to a generation of neurotoxin quinolinic acid, was studied. In particular, the putative receptor for amyloid. peptide expressed in activated macrophages infiltrating into amyloid plaques was tried to be characterized.